Fig. 6: Ultrasound-driven implantable PTENG for wireless deep brain stimulation and neuromodulation. | npj Flexible Electronics

Fig. 6: Ultrasound-driven implantable PTENG for wireless deep brain stimulation and neuromodulation.

From: Advances in flexible piezoelectrics for wearable and implantable medical devices

Fig. 6: Ultrasound-driven implantable PTENG for wireless deep brain stimulation and neuromodulation.The alternative text for this image may have been generated using AI.

a Schematic illustrating wireless DBS using PVDF/TMCM-MnCl3-based PENG for ultrasound-driven ES. b Illustration of ultrasound-driven DBS using a subcutaneously implanted PTENG, with Parkinson’s disease model rats receiving 30-min daily ultrasound treatments for 4 weeks. c Open field test tracking locomotor activity pre-treatment and on days 1 and 28 post-treatment. d Power spectral density of the striatum before and after 30 min of DBS, showing reduced beta oscillations. Quantitative assessments of motor function in the open field test: e total distance travelled, f maximum speed and g activity time across different experimental groups (n = 6, P < 0.05)149. Reproduced with permission. Copyright 2023, American Chemical Society.

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