Table 4 Dopaminergic basis of NMSS Domain 4 (perception disorders) pathophysiology in PD

From: Presynaptic dopaminergic terminal imaging and non-motor symptoms assessment of Parkinson’s disease: evidence for dopaminergic basis?

Author

Year

NMS

Radiotracer

Demographics

Results

Analysis

Kiferle et al.135

2014

VH

123I-FP-CIT

18 non-demented PD patients with VH and 18 non-demented PD patients without VH.

Significant reduction in baseline right caudate uptake (p < 0.05) in patients with VH. With regards to putamen and contralateral caudate uptake, no significant differences were observed between groups.

Not a particularly notable study as the groups studied are difficult to define and role of medication induced hallucinations complicates the findings. The study lacks baseline neuropsychological evaluation, which would have been useful.

  1. 123 I-FP-CIT [123I]-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane, PD Parkinson’s disease, VH visual hallucinations
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