Table 5 Dopaminergic basis of NMSS Domain 5 (attention and memory) pathophysiology in Parkinson’s disease
Author | Year | NMS | Radiotracer | Demographics | Results | Analysis |
|---|---|---|---|---|---|---|
Rinne et al.111 | 2000 | Attention | 18F-DOPA | 28 PD patients and 16 healthy controls were assessed via MMSE, detailed neuropsychological assessment including tests for frontal lobe function. | Reduction of 18F-DOPA uptake in the caudate and frontal cortex is associated with a poor performance in tests requiring working memory and attention (p = 0.001). | This controlled early PET study highlights the possible dopaminergic basis of working memory and attention. |
Brück et al.99 | 2005 | Attention | 18F-DOPA | 21 non-medicated patients, non-demented PD patients and 24 healthy controls. | Increased tracer uptake in the medial frontal cortex and anterior cingulate correlated negatively with reaction time requiring suppressed attention (p = 0.01). Increased uptake in dorsolateral prefrontal cortex showed a positive correlation with sustained attention (p = 0.014). | This is an important controlled PET study showing a possible role of compensatory cortical mechanisms at play. The study did have a large interval between neuropsychological testing and imaging (66 days on average) which may be need to be shorter in a subsequent study. |
