Table 6 Dopaminergic basis of NMSS Domain 6 (urinary dysfunction) pathophysiology in PD
Author | Year | NMS | Radiotracer | Demographics | Results | Analysis |
|---|---|---|---|---|---|---|
Sakakibara et al.150 | 2001 | Urinary | 123I-β-CIT | 11 PD patients with LDOPA treatment. | Reduction in nigrostriatal dopaminergic function, notably in the caudate (p = 0.01, right side; 0.05, left side), anterior and posterior putamen (p = 0.05, both right side) of the group of patients with urinary dysfunction. | This is one of the few studies addressing a key non-motor symptom, urinary dysfunction. However, the finding is non-specific and do not suggest a strong pathophysiological basis. Furthermore, the urinary dysfunction symptoms were not represented well in the small sample and no urodynamic evaluation was obtained. |
Winge et al.201 | 2005 | Urinary | 123I-FP-CIT | 18 PD patients underwent imaging. | Patients with bladder symptoms had reduced uptake in the putamen and caudate (p = 0.03) with correlation in caudate degeneration and symptom severity. | The study suggests a dopaminergic basis for LUTS. Another study of urinary dysfunction with non-specific findings. The relationship with caudate is interesting and warrants further exploration. Lack of controls and the arbitrary cut off in the urinary questionnaire, limits the validity. |
