Fig. 5
From: Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat
Treatment with paraquat + lectin induces loss of TH-positive neurons in the SNpc. Representative images of TH-positive neurons in SNpc of control a and treated animals b. Insets are higher magnifications of the boxed areas in the respective panels. Calibration bar: 100 µm. Graphic summary of TH-IR neuronal number in both the left c and right d SNpc of control (white) and P + L treated (black) rats. Note that a significant loss of neurons was detected in SNpc of animals 4 weeks after the last gavage of paraquat + lectin (n = 3 for controls and 4 for P + L 4 weeks, respectively; *p < 0.05 vs. control). d Graphic summary showing that the mean estimate number of TH-IR neurons is not significantly different from the mean estimate number of CV-positive neurons in the SNpc of P + L treated animals (n = 4)
