Table 1 Overview of the key results.

From: Hypomania and saccadic changes in Parkinson’s disease: influence of D2 and D3 dopaminergic signalling

Patients

 

All (n = 33)

Correlation with HPS

  

   VGS

 

Duration

r = 0.50; p = 0.003

  
 

Gain

n.s.

  
 

Latency

n.s.

  
 

Amplitude

n.s.

  

   MGS

 

Duration

r = 0.49; p = 0.004

  
 

Gain

n.s.

  
 

Latency

n.s.

  
 

Amplitude

n.s.

  
 

DRD2+ (n = 12)

 

DRD2– (n = 21)

 
 

Mean (SE)

Correlation with HPS

Mean (SE)

Correlation with HPS

   VGS

Duration

92.14 (SE: 1.14)

n.s.

92.1 (SE: 0.94)

r = 0.49; p = 0.024

Gain

0.79 (SE: 0.04)

n.s.

0.79 (SE: 0.02)

n.s.

Latency

514.9 (SE: 12.2)

r = 0.61; p = 0.036

506.3 (SE: 7.2)

n.s.

Amplitude

5.097 (SE: 0.32)

n.s.

5.557 (SE: 0.38)

n.s.

   MGS

Duration

86.98 (SE: 1.60)

n.s.

89.7 (SE: 1.06)

r = 0.47; p = 0.033

Gain

0.60 (SE: 0.007)

r = 0.72; p = 0.009

0.66 (SE: 0.03)

n.s.

Latency

511.2 (SE: 18.39)

n.s.

529.6 (SE: 8.72)

n.s.

Amplitude

3.923 (SE: 0.30)

n.s.

4.377 (SE: 0.32)

n.s.

 

DRD3+ (n = 14)

 

DRD3− (n = 19)

 
 

Mean (SE)

Correlation with HPS

Mean (SE)

Correlation with HPS

   VGS

Duration

92.62 (SE: 1.07)

n.s.

91.75 (0.98)

r = 0.62; p = 0.005

Gain

0.74 (SE: 0.03)*

n.s.

0.8274 (SE:0.02)*

n.s.

Latency

511.7 (SE: 9.9)

n.s.

507.7 (SE: 8.4)

r = 0.52; p = 0.022

Amplitude

5.243 (SE: 0.42)

n.s.

5.497 (SE: 0.35)

r = 0.62; p = 0.005

   MGS

Duration

89.97 (SE: 1.31)

n.s.

87.77 (SE: 1.22)

r = 0.55; p = 0.015

Gain

0.65 (SE: 0.03)

r = 0.63; p = 0.016

0.63 (SE: 0.04)

n.s.

Latency

545.3 (SE: 11.45)*

n.s.

506.4 (SE: 11.22)*

n.s.

Amplitude

4.214 (SE: 0.42)

n.s.

4.21 (SE: 0.28)

r = 0.61; p = 0.006

Controls

 

All (n = 14)

   
 

Mean (SE)

   

   VGS

Duration

97.49 (SE: 0.83)

   

Gain

0.74 (SE: 0.05)

   

Latency

514.82 (16.49)

   

Amplitude

6.01 (SE: 0.57)

   

   MGS

Duration

96.66 (SE: 1.22)

   

Gain

0.65 (SE: 0.07)

   

Latency

519.55 (SE: 12.62)

   

Amplitude

5.15 (SE: 0.56)

   
  1. *Significant at p < 0.05
  2. Patients: Visualised are the key results of the regression analysis between the visually guided (VGS) and memory-guided saccades (MGS) and the hypomania scale (HPS). The upper table shows results of the whole parkinsonian group. In the lower table regression analysis is subdivided into the individual genotypes [D2 receptor: (+) risk variant; (−) wild type; D3 receptor (+) risk variant; (−) wild type]. We additionally integrated the individual group sizes (n) for better interpretation
  3. Controls: For better interpretation of results we present individual saccade parameters of duration, gain, latency and amplitude also for the healthy controls in both VGS and MGS conditions
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