Table 1 Mechanisms involved in the pathogenesis of viral-induced parkinsonism.
From: COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside
Mechanism | Type of neuronal damage |
|---|---|
Virus tropism for basal ganglia, replication and subsequent neuronal lysis | Direct |
Microglia activation and release of pro-inflammatory factors and T cell response | Indirect |
Hypercytokinemia and loss of vascular integrity | Indirect |
Hypoxic brain injury | Indirect |
