Table 2 Discriminative measures of FDG PET and MIBG scintigraphy.

From: Differential diagnosis of parkinsonism: a head-to-head comparison of FDG PET and MIBG scintigraphy

Analysis

Modality

ROC AUC

Sensitivity

Specificity

PPV

NPV

LR+

LR−

A

MIBG

0.69 (0.53–0.85)

0.91 (0.47–1.00)

0.53 (0.32–0.95)

0.78 (0.71–0.94)

0.77 (0.47–1.00)

1.92 (1.26–3.53)

0.17 (0.00–0.45)

FDG

0.82 (0.68–0.97)

0.94 (0.82–1.00)

0.74 (0.53–0.95)

0.86 (0.78–0.96)

0.88 (0.70–1.00)

3.58 (1.99–14.06)

0.08 (0.00–0.22)

B

MIBG

0.69 (0.52–0.86)

0.93 (0.46–1.00)

0.47 (0.29–0.94)

0.74 (0.69–0.95)

0.80 (0.48–1.00)

1.75 (1.17–3.10)

0.15 (0.04–0.45)

FDG

0.82 (0.67–0.98)

0.96 (0.75–1.00)

0.71 (0.47–0.94)

0.84 (0.76–0.96)

0.92 (0.68–1.00)

3.28 (1.72–8.44)

0.05 (0.00-0.18)

  1. Values in parentheses give 95% confidence intervals.
  2. A analysis for the differentiation of Lewy body diseases versus diseases without Lewy bodies, B analysis for the differentiation of Parkinson’s disease versus multiple system atrophy, MIBG MIBG scintigraphy, FDG FDG positron emission tomography, ROC AUC area under the receiver operating characteristic curve, PPV positive predictive value, NPV negative predictive value, LR+ positive likelihood ratio, LR− negative likelihood ratio.
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