Fig. 1: Alterations of dopaminergic striatal levels may lead to hypo- or hyper-honesty in PD.
From: Human moral decision-making through the lens of Parkinson’s disease
Schematic overview of the role of dopaminergic striatal levels in explaining the behavioral transition from the purported dynamic balance of health condition to the unbalance that leads to hypo- or hyper-honesty in PD. The dopaminergic imbalance between the ventral and dorsal striatum may alter the brain motivation system and thus enhance/decrease the salience of reward-related stimuli. Altered incentive salience (i.e., “wanting”) may in turn explain the hypo- and hyper-honest behavioral tendencies expressed by PD patients during deceptive decision-making. This model is inspired by a recent meta-analysis90. The hypo- and hyper-honest behavioral tendencies have been displayed respectively on the left and right side of the figure only for representational purposes. No hypothesis on brain lateralization has been proposed.
