Fig. 1: Structure of 14-3-3.

Orthogonal views of human 14-3-3θ/τ, modified from 6BD1²²⁶. a Schematic representation of the main structure of human 14-3-3θ/τ showing the spatial allocation of the amphipathic groove. b Some of the most significant residues involved in structure stability and functionality. Some isoform-specific mutations are depicted: Arg83* is replaced by Glu83 in the 14-3-3σ isoform and involved in Lys9-Glu83 binding. Ala58** is present only in isoforms -θ/τ and -σ; all the other isoforms present a Ser58 which is a very important phosphorylation site (see main text). Ser175*** indicated as Ser184/186 in the main text. C: C-terminal, N: N-terminal.