Fig. 1: Comparison of DTI, NODDI, FWE-DTI, and MT-sat.
From: White matter and nigral alterations in multiple system atrophy-parkinsonian type
Diffusion tensor imaging (DTI, fractional anisotropy [FA], mean diffusivity [MD], axial diffusivity [AD], and radial diffusivity [RD]) (a), neurite orientation dispersion and density imaging (NODDI, intracellular volume fraction [ICVF], orientation dispersion index [ODI], and isotropic volume fraction [ISOVF]) (b), free-water elimination DTI (FWE-DTI, FW, free water-corrected FA [FAT], free water-corrected MD [MDT], free water-corrected AD [ADT], and free water-corrected RD [RDT]) (c), and magnetization transfer-saturation (MT-sat, myelin volume fraction [MVF]) (d) indices. Tract-based spatial statistics (TBSS) analyses showed that MSA-P patients had significantly (P < 0.05, FWE-corrected) lower (blue/light blue voxels) FA, ICVF, MVF, and ADT, and higher (red-yellow voxels) MD, AD, RD, ODI, ISOVF, FW, FAT, MDT, and RDT than healthy controls, and significantly higher (blue/light blue voxels) MD, RD, FW, and RDT, and lower (red-yellow voxels) FA, ICVF, and FAT than Parkinson’s disease patients. MSA-P patients showed lower (blue/light blue voxels) ICVF and MVF, and higher (red-yellow voxels) MD, AD, RD, ODI, ISOVF, FW, and FAT, compared with Parkinson’s disease patients. There were no significant differences in MVF between the groups (see Supplementary Table 2). The TBSS results were very similar in the second cohort (see Supplementary Table 3). The skeleton is presented in green. To aid visualization, the results are thickened using the fill script implemented in the FMRIB Software Library.
