Fig. 5: Cofilin 1 promotes the degeneration of dopaminergic neurons induced by α-synuclein fibrils in vivo. | npj Parkinson's Disease

Fig. 5: Cofilin 1 promotes the degeneration of dopaminergic neurons induced by α-synuclein fibrils in vivo.

From: Cofilin 1 promotes the pathogenicity and transmission of pathological α-synuclein in mouse models of Parkinson’s disease

Fig. 5: Cofilin 1 promotes the degeneration of dopaminergic neurons induced by α-synuclein fibrils in vivo.

a–c TH immunostaining of the striatum and substantia nigra (SN). The number of TH-positive neurons in the SN and the density of striatal dopaminergic terminals were quantified. Scale bars, 100 μm. Data are mean ± SEM; n = 4–5; *P < 0.05, **P < 0.01, ****P < 0.0001, ns: not statistically significant by one-way ANOVA. d, e Concentrations of DA and DOPAC in the striatal tissues, as determined by HPLC. Data are mean ± SEM; n = 4 mice per group; *P < 0.05 by one-way ANOVA. f, g Cofilin 1 promotes microglia activation. Immunostaining showing the Iba1-positive microglia in the striatum. Scale bar, 20 μm. Data are mean ± SEM; n = 5; *P < 0.05, ***P < 0.001 by one-way ANOVA.

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