Fig. 6: Cofilin 1 enhances behavioral impairments induced by α-synuclein fibrils.

Behavioral performance. The behavioral impairments were more severe when cofilin 1 was overexpressed with α-synuclein fibrils, as demonstrated by rotarod test (a), balance beam test (b), pole test (c), wire hang test (d), and tail suspension test (e). Data are mean ± SEM; n = 9 mice per group; *P < 0.05, **P < 0.01, ****P < 0.0001 by one-way ANOVA. (f) Representative images showing the hindlimbs clasp in tail suspension test.