Fig. 2: Relationship between GABAergic response to dopamine agonist therapy and impulsivity.
From: Dopamine-induced changes to thalamic GABA concentration in impulsive Parkinson disease patients
Partial correlation between the pharmacological effect of dopamine agonist (DAA) on thalamic GABA (ΔGABA) and the Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease-Rating Scale (QUIP-RS) score. ΔGABA values are adjusted for age and DAA dosage. The QUIP-RS score is a clinical measure of ICB symptom severity, in which higher values represent the predilection towards reward-based behaviors. The regression analysis showed that higher QUIP-RS scores were associated with lower thalamic ΔGABA (p = 0.027), while adjusting for age and DAA dosage.
