Fig. 4: Neuropeptide alterations in sub-regions of caudate and putamen associated with LID.
From: Basal ganglia neuropeptides show abnormal processing associated with L-DOPA-induced dyskinesia
a Optical image of a macaque brain section at ac -6 mm51, showing subregional divisions of the Put and BCd. b, c Heat maps showing z-scores for each group of peptides with variable importance in projection values (VIP) > 1 in sub-regions of the BCd and Put, respectively. Asterisks indicate the significance of differences in neuropeptide levels between non-LID and LID animals according to the Mann–Whitney test with the false discovery rate (FDR) correction (N = 5, *P ≤ 0.05; **P ≤ 0.01). The scale bar is 2 mm. BCd body of the caudate nucleus, DL Dorsolateral, DM dorsomedial, GPe external globus pallidus, GPi internal globus pallidus, IL intermediolateral, IM intermediomedial, Put putamen, SN substantia nigra, TCd tail of the caudate nucleus, VL ventrolateral, VM ventromedial.
