Fig. 1: Between-group differences in FDG and FDOPA uptake versus healthy controls.
From: Longitudinal trimodal imaging of midbrain-associated network degeneration in Parkinson’s disease
T-maps were generated in SPM12 by voxel-vise t-tests with the above displayed contrasts. a Patients with Parkinson’s disease showed FDG hypometabolism at baseline and follow-up visit in comparison to healthy controls. Extracted normalized FDG uptake (b) and FDOPA uptake (d) values from respective clusters (FU < HC) are shown as boxplots with individual data points in a direct comparison between baseline, follow-up, and healthy controls (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, central line = median, bounds of box = 25th to 75th percentile, whiskers = smallest to highest value within 1.5 times interquartile range below 25th percentile respectively above 75th percentile). c Patients exhibited dopaminergic deficits in the bilateral posterior putamen compared to healthy controls at both visits. Results are shown at pFWE < 0.05 cluster-level corrected using SVC for a midbrain (a) or striatum (c) ROI. T-values of resulting clusters are indicated by the colorbar. Boxplots contain extracted normalized FDG and FDOPA values with proportional scaling. BL = baseline, FU = follow up, HC = healthy controls, PUTl = left putamen, PUTr = right putamen, CAUr = right caudate nucleus.
