Fig. 6: Illustration of effect sizes for steps 1 and 2 in a screening-adapted version of the PREDIGT Score (Model 2) using three distinct objective test results in Step 2. | npj Parkinson's Disease

Fig. 6: Illustration of effect sizes for steps 1 and 2 in a screening-adapted version of the PREDIGT Score (Model 2) using three distinct objective test results in Step 2.

From: Evaluation of the PREDIGT score’s performance in identifying newly diagnosed Parkinson’s patients without motor examination

Fig. 6

In a and d olfaction was measured by Sniffin’ Sticks test; b and e depression measured by the Beck’s Depression Inventory (BDI); c and f total α-synuclein concentration measured in the cerebrospinal fluid. Panels a–c show the relation between the Step 1 PREDIGT Questionnaire score (x-axis) and Step 2 test score (y-axis) by scatter plots with corresponding score densities. In a–c, blue represents the healthy control group (HC), red represents the group of Parkinson’s disease patients (PD). In d–f, corresponding, extended ROC plots are shown. Vertical, dashed, green lines in panels a–c represent the Step 1 thresholds corresponding to the largest combined AUC of Model 2, also represented in d–f by a green line. Black and purple ROC curves represent the Step 1 questionnaire and the Step 2 clinical test, separately. AUC, value for the area under the receiver operating characteristic (ROC) curve.

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