Fig. 5: Harmol rescues behavioral deficits in A53T α-syn mice. | npj Parkinson's Disease

Fig. 5: Harmol rescues behavioral deficits in A53T α-syn mice.

From: Harmol promotes α-synuclein degradation and improves motor impairment in Parkinson’s models via regulating autophagy-lysosome pathway

Fig. 5: Harmol rescues behavioral deficits in A53T α-syn mice.

a Experimental protocol for A53T α-syn mice. b Pole test. Quantification of the pole-climbing time for each treatment (mean ± SEM). ###P < 0.001 vs. the wild-type (saline). *P < 0.05 and **P < 0.01 vs. the A53T Tg. c Rotarod test. Quantification of the latency time on the rotarod for each treatment (mean ± SEM). #P < 0.05 and ###P < 0.001 vs. the wild-type (saline). *P < 0.05 vs. the A53T Tg. d Open-field test. Quantification of the total distance traveled in the open-field test for each treatment (mean ± SEM). ###P < 0.001 vs. the wild-type (saline). *P < 0.05, **P < 0.01, and ***P < 0.001 vs. the A53T Tg. e Representative exploratory patterns of mice in each group. f–l Automated treadmill gait test. Quantification of the stance width (f), step angle (g), stride frequency (h), stance (i), stride (j), swing (k), and absolute paw angle (l) for each treatment (mean ± SEM). #P < 0.05, ##P < 0.01 and ###P < 0.001 vs. the wild-type (saline). *P < 0.05, **P < 0.01 and ***P < 0.001 vs. the A53T Tg.

Back to article page