Fig. 2: Voxel-wise group comparison of putaminal microstructure between patients with PD and healthy controls. | npj Parkinson's Disease

Fig. 2: Voxel-wise group comparison of putaminal microstructure between patients with PD and healthy controls.

From: Disentangling nigral and putaminal contribution to motor impairment and levodopa response in Parkinson’s disease

Fig. 2

Voxel-wise group comparison of DMI parameters between patients with PD (n = 108) and healthy controls (n = 35) superimposed on a T1w MRI template in standard space. The analysis controlled for age and sex, and a 5% false discovery rate (FDR) was applied. Top row: The standardized regression coefficients were extracted from regression models both in PD and HC groups (with the covariates “age” and “sex”). Color-coding indicates the coefficient values as a measure of effect size of the factor “Parkinson’s disease” on DMI-parameters (hot colors: positive effect size vs. cold colors: negative effect size). Bottom row: Significant results of the voxel-wise group comparisons with a 5% FDR. The right putamen is shown in green. The left side of the image corresponds to right side of the patient’s body. DMI diffusion microstructure imaging, FDR false discovery rate, V-CSF compartment of free interstitial fluid, V-extra compartment of somata and unmyelinated axons, V-intra intra-axonal and dendritic compartment.

Back to article page