Table 2 Causative pathogenic and likely pathogenic variants.

Patient	Age of onset (years)	Patient group	Gene variant	Class	Applied ACMG criteria^a
P006	41	EOPD	GBA NM_000157.4:c.1226A > G	P	PS3, PM2, PM3_VSTR, PP2
P012	57	FPD
P014	68
P015	69
P002	32	EOPD	GBA NM_000157.4:c.1448T > C	P	PS3, PM2, PM3_VSTR, PP2
P003	46	EOPD
P013	59	FPD
P007	43	EOPD	GBA NM_000157.4:c.586A > C	LP	PS3, PM2, PM3, PP2
P001	49	EOPD
P011	51	FPD
P005	36	EOPD	GBA NM_000157.4:c.1289C > T	P	PS3, PM2, PM3_STR, PP2
P004	50	EOPD	GBA NM_000157.4:c.1289C > T	P	PS3, PM2, PM3_STR, PP2
P010	50	FPD	GBA NM_000157.4:c.1090G > A	P	PS3_MOD, PM2, PM3_STR, PM5_SUP, PP2
P009	36	FPD	GBA NM_000157.4:c.115 + 1G > A	P	PVS1, PM2, PM3_VSTR
P008	34	EOPD	PARK2 NM_004562.3:c.823C > T	P	PS3, PM2, PM3_VSTR, PP2
P008	34	EOPD	PARK2 Exon 5 deletion	LP	PVS1_MOD, PM3_STR, PM2

P pathogenic, LP likely pathogenic, EOPD sporadic early-onset PD, FPD familial PD,
^aACMG criteria modifiers = very strong (VSTR), strong (STR), moderate (MOD), or supporting (SUP).

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