Fig. 5: Distribution of polygenic scores in relation to MDS-UPDRS subpart and total progression.
From: Genetically-informed prediction of short-term Parkinson’s disease progression
Distribution of polygenic scores for Parkinson’s disease diagnosis (left column) and Educational attainment (right column), by MDS-UPDRS subparts and Total progressors (red) and non-progressors (blue). Distribution overlaps are colored purple. The Parkinson’s disease PRS has a right tail that is more prominent in non-progressors, likely capturing a genetic subgroup of Parkinson’s disease due to high polygenic risk. The Educational attainment PRS is normally distributed with a minor left shift in the distribution for motor non-progressors.
