Fig. 3: C/EBPβ/AEP pathway mediates neuro-inflammation in α-SNCA transgenic mice. | npj Parkinson's Disease

Fig. 3: C/EBPβ/AEP pathway mediates neuro-inflammation in α-SNCA transgenic mice.

From: C/EBPβ/AEP is age-dependently activated in Parkinson’s disease and mediates α-synuclein in the gut and brain

Fig. 3: C/EBPβ/AEP pathway mediates neuro-inflammation in α-SNCA transgenic mice.

a Immunostaining and the quantification of Iba-1 in the striatum and SN. (n = 5–6 per group, *P < 0.05 vs 14 months old α-SNCA transgenic mouse, one-way ANOVA). Scale bar, 50 μm. b 4-HNE staining and the quantification in the SN. (n = 5–6 per group, *P < 0.05 vs 14 months old α-SNCA transgenic mouse, one-way ANOVA). Scale bar, 20 μm. c Reduction of C/EBPβ and knockdown of delta-secretase decreases the expression levels of inflammatory cytokines in α-SNCA transgenic mice. (n = 3 per group, *P < 0.05 vs 14 months old α-SNCA transgenic mouse, one-way ANOVA). d Immunostaining of TH in the striatum and SN, and the quantification of TH in SN. (n = 5–6 per group, *P < 0.05 vs 14 months old α-SNCA transgenic mouse, one-way ANOVA). Scale bar, 500 μm. e Rotarod test and Grid test. (mean ± s.e.m.; n = 8 mice per group; *P < 0.05 vs 14 months old α-SNCA transgenic mouse, one-way ANOVA).

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