Fig. 4: C/EBPβ/AEP signaling regulates Lewy body-like pathology in α-SNCA transgenic mice. | npj Parkinson's Disease

Fig. 4: C/EBPβ/AEP signaling regulates Lewy body-like pathology in α-SNCA transgenic mice.

From: C/EBPβ/AEP is age-dependently activated in Parkinson’s disease and mediates α-synuclein in the gut and brain

Fig. 4: C/EBPβ/AEP signaling regulates Lewy body-like pathology in α-SNCA transgenic mice.

Immunofluorescent co-staining of p-α-Syn 129 and ThS (a) and p-α-Syn 129 and Ub (b) in SN. Quantification of the immunostaining (n = 5–6 per group, *P < 0.05 vs 14 months old α-SNCA transgenic mouse, one-way ANOVA). Scale bar, 20 μm. c p-α-Syn 129 immunostaining of the cortex, striatum, and SN. Quantification of the IHC staining (n = 5–6 per group, *P < 0.05 vs 14 months old α-SNCA transgenic mouse, one-way ANOVA). Scale bar, 50 μm. d Heat map colors represent the extent of p-α-Syn 129 pathologies (white (0), no pathology; red (3), the maximal pathology). Immunofluorescent co-staining and the quantification of p-α-Syn 129 and ThS (e) and p-α-Syn 129 and Ub (f) in the colon. (n = 5–6 per group, *P < 0.05 vs 14 months old α-SNCA transgenic mouse, one-way ANOVA). Scale bar, 50 μm.

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