Fig. 5: Knockout of C/EBPβ/AEP pathway alleviates constipation in α-SNCA transgenic mice. | npj Parkinson's Disease

Fig. 5: Knockout of C/EBPβ/AEP pathway alleviates constipation in α-SNCA transgenic mice.

From: C/EBPβ/AEP is age-dependently activated in Parkinson’s disease and mediates α-synuclein in the gut and brain

Fig. 5: Knockout of C/EBPβ/AEP pathway alleviates constipation in α-SNCA transgenic mice.

a Gastrointestinal (GI) tract transit time and water content of stool in the mice. (n = 3 per group, *P < 0.05 vs rotenone treated α-SNCA transgenic mouse, one-way ANOVA). Western blot showing C/EBPβ, AEP, MPO, TH, α-Syn, and p-α-Syn 129 expressing in the mouse colon (b) and C/EBPβ, AEP, TH, α-Syn, and p-α-Syn 129 expressed in the mouse brain (c). Quantification of western blotting (n = 4 per group, *P < 0.05 vs rotenone treated α-SNCA transgenic mouse, one-way ANOVA).

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