Fig. 6: C/EBPβ/AEP axis mediates Lewy body-like pathology propagation from the gut into the brain in α-SNCA mice. | npj Parkinson's Disease

Fig. 6: C/EBPβ/AEP axis mediates Lewy body-like pathology propagation from the gut into the brain in α-SNCA mice.

From: C/EBPβ/AEP is age-dependently activated in Parkinson’s disease and mediates α-synuclein in the gut and brain

Fig. 6: C/EBPβ/AEP axis mediates Lewy body-like pathology propagation from the gut into the brain in α-SNCA mice.

Immunofluorescent co-staining of p-α-Syn 129 and ThS in the colon (Scale bar, 20 μm), vagus nerve (Scale bar, 50 μm), DMVN (Scale bar, 100 μm), and SN (Scale bar, 20 μm) in the α-SNCA transgenic mouse after 0-week (a), 3 weeks (b), 6 weeks (c), and 12 weeks (d) rotenone treatment. e Reduction of C/EBPβ and knockdown of AEP block the spreading of p-α-Syn 129 co-stained with ThS.

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