Fig. 7: C/EBPβ/AEP signaling is upregulated in PD patient brain and gut. | npj Parkinson's Disease

Fig. 7: C/EBPβ/AEP signaling is upregulated in PD patient brain and gut.

From: C/EBPβ/AEP is age-dependently activated in Parkinson’s disease and mediates α-synuclein in the gut and brain

Fig. 7: C/EBPβ/AEP signaling is upregulated in PD patient brain and gut.

a Western blot and the quantification showing C/EBPβ, AEP, TH, and α-Syn expressing and processing in PD patients and Control. (n = 4 per group, *P < 0.05 vs Control, Student’s t-test, two-tailed). Immunofluorescent co-staining of p-α-Syn 129 and TH (b) and co-staining of p-α-Syn 129 and ThS (c) in SN of PD patients and Control. Quantification of the immunostaining (n = 4 per group, *P < 0.05 vs Control, Student’s t-test, two-tailed). Scale bar, 100 μm. Immunofluorescent co-staining of N103 and ThS (d) and co-staining of CEBP/β and AEP, CEBP/β and TH, AEP, and TH (e) in the colon of PD patients and healthy control (human biopsy samples with the mucosal/submucosal layer). Quantification of the immunostaining (n = 4 per group, *P < 0.05 vs Control, Student’s t-test, two-tailed). Scale bar, 50 μm.

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