Fig. 5: DOPA-MSCs improved PD symptoms by secreting dopamine transmitters. | npj Parkinson's Disease

Fig. 5: DOPA-MSCs improved PD symptoms by secreting dopamine transmitters.

From: Genetically engineered mesenchymal stem cells with dopamine synthesis for Parkinson’s disease in animal models

Fig. 5

a Radioactive uptake images of the position of the basal ganglia before and 6 months after DOPA-MSC transplantation in chronic PD monkeys (n = 3). Scale bars, 1 cm. b Quantification of the radiation ratios of the left and right basal ganglia before and after DOPA-MSC transplantation in chronic PD monkeys. Data are presented as the mean ± s.d. (n = 3). Significance was assessed by a two-tailed Student’s t-test. *p < 0.05; **p < 0.01; ***p < 0.001. c Correlation between the ratio of radioactive uptake in the left basal ganglia and behavioral results in the Bi-ventricle MPP+ group. Two-tailed Pearson’s correlation analysis was performed, and r and P values are shown. SLA spontaneous locomotor activity. d Detection of dopamine concentrations in cerebrospinal fluid from different treatment monkeys. Data are presented as the mean ± s.d. (n = 3). Significance was assessed by a two-tailed Student’s t-test, *p < 0.05; **p < 0.01; ***p < 0.001.

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