Fig. 3: Comparative outcomes of peripheral blood and cerebrospinal fluid biomarkers in the systematic review.
From: A systematic review and meta-analysis of inflammatory biomarkers in Parkinson’s disease
The peripheral blood (a) and cerebrospinal fluid (b) inflammatory markers with significant effect sizes (Hedges’ g) were displayed in comparisons for PD patients versus controls. Violet spots indicate Hedges’ g of each marker, and blue and orange bars indicate the number of studies included. CCL chemokine (C-C motif) ligand, CSF macrophage-colony stimulating factor, CXCL chemokine (C-X-C motif) ligand, FGF fibroblast growth factor, GRO growth-regulated oncogene, IL interleukin, HMGB high-mobility group box, MCP monocyte chemoattractant protein, MEC mucosae-associated epithelial chemokine, MIP macrophage inflammatory protein, NGAL neutrophil gelatinase-associated lipocalin, NGF nerve growth factor, PD Parkinson’s disease, PDGFB platelet-derived growth factor-B, PTX pentraxin, PD-L programmed death-ligand, SCF stem cell factor, SDF stromal cell-derived factor, sVCAM soluble vascular cell adhesion molecule, VEGF-A vascular endothelial growth factor A.
