Table 3 Baseline demographics, clinical characteristics, mean striatal DaT SBR and BMP concentrations (adjusted for age and sex) in GBA1 N409S + PD, N409S + NMC, sPD, and HC.

From: LRRK2 and GBA1 variant carriers have higher urinary bis(monacylglycerol) phosphate concentrations in PPMI cohorts

 

1

2

3

4

   
 

N409S+ PD n = 76

N409S+ NMC n = 178

sPD n = 379

HC n = 190

P value 1 vs 2

P value 1 vs 3

P value 2 vs 4

Age (years), mean (SD)a

62.79 (10.22)

62.15 (6.71)

61.94 (9.66)

60.67 (11.16)

   

Age at onset (years), mean (SD)

58.52 (10.88)

 

59.94 (9.93)

 

N/A

0.2945

N/A

Mean Striatal DaT SBR, mean (SD)

missing

1.28 (0.52)

2.79 (0.57)

1.39 (0.39)

2.57 (0.56)

<0.0001

0.1003

0.7039

13

5

4

3

Disease duration (months), median

(range)

31.72

 

4.2

 

N/A

<0.0001α

N/A

(0.30, 85.23)

(0.40, 35.83)

Female Sex, n (%)

33 (43.42%)

106 (59.55%)

129 (34.04%)

67 (35.26%)

0.0180

0.1189

<0.0001

MDS-UPDRS III Off, mean (SD)

missing

26.87 (11.11)

2.60 (3.90)

20.89 (8.79)

1.19 (2.15)

<0.0001

0.0001

<0.0001

15

1

0

2

MoCA, median (range)

missing

27

27

28

28

0.2107α

0.0056α

<0.0001α

(15.00, 30.00)

(16.00, 30.00)

(17.00, 30.00)

(26.00, 30.00)

0

0

0

0

Total di-18:1-BMP, median (range)b

5.20

4.38

3.53

3.77

   

(0.70, 26.49)

(0.38, 33.51)

(0.21, 38.02)

(0.39, 22.03)

Total di-22:6-BMP, median (range)

14.14

14.51

10.61

10.42

0.9184

0.0014

<0.0001

(3.74, 88.97)

(3.16, 115.74)

(1.18, 76.76)

(1.25, 85.89)

2,2’-di-22:6-BMP, median (range)

9.65

9.54

6.83

6.37

0.9248

0.0001

<0.0001

(2.22, 66.35)

(0.81, 87.08)

(0.81, 59.27)

(0.60, 65.96)

  1. Pairwise comparisons that showed significance at p value <0.0125 (after Bonferroni correction applied due to multiple comparisons) are shown in bolded font.
  2. PD Parkinson’s disease, NMC non-manifesting carriers, sPD sporadic PD, HC healthy control, SD standard deviation, DaT dopamine transporter, SBR specific binding ratio, MDS-UPDRS movement disorders society-unified Parkinson’s disease rating scale, MoCA Montreal cognitive assessment, BMP bis(monoacylglycerol)phosphate.
  3. αComputed using Mann–Whitney U-test.
  4. aThe overall F-test was non-significant thus pairwise comparisons were not computed.
  5. bThe overall test was non-significant thus pairwise comparisons were not computed.
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