Fig. 3: Amygdala subregion-specific comprehensive clinical-functional signatures in PD.

a Brain scores and behavior scores of LV-1 demonstrate significant correlations in each subregion. Individuals who exhibited the FC pattern in c tend to exhibit corresponding behavioral phenotypes in b. The colors in a represent different subregions. b Subregion-specific clinical features. The correlation of each subregion to each clinical feature is shown using correlation coefficients. Error bars indicate bootstrap estimated 95% confidence intervals of correlation strength. The colors in b represent the different categories of clinical symptoms. c Subregion-specific FC maps associate with clinical features. Patients who exhibit these FC patterns tend to score worse regarding clinical symptoms. The contribution of hypo-connectivity voxels on clinical features is shown using bootstrap ratio (BSR), thresholding at BSR > 3.3 (P < 0.001, MNI 152 space). A larger BSR represents a greater contribution to the LV that represent the relationship between hypo-connectivity features and NMS. LEDD levodopa-equivalent daily dose, TIV total intracranial volume, OH orthostatic hypotension.