Fig. 3: Plasma measures in relation to clinical assessment scales in MSA and its subtypes.
From: Head-to-head comparison of 6 plasma biomarkers in early multiple system atrophy
a The left heat map showed correlations of clinical scales with plasma biomarkers, with colors representing the correlation coefficients (β) of multiple linear regressions. The color bar represents the range of β values. Models were adjusted for age and sex. Significance: ***p < 0.001, **p < 0.01, *p < 0.05, -p ≥ 0.05. b The right scatter plots displayed significantly positive associations between NfL or GFAP and clinical scores. Αβ amyloid-β, ADL Activity of Daily Living Scale, AVLT Auditory Verbal Learning Test, BNT Boston Naming Test, COMPASS Composite Autonomic Symptom Score, DST Digit Span Test, GFAP glial fibrillary acidic protein, HAMA Hamilton Anxiety Scale, HAMD Hamilton Depression Scale, ICARS International Cooperative Ataxia Rating Scale, MBI-C Mild Behavioral Impairment Checklist, MMSE Mini-Mental State Examination, MoCA Montreal Cognitive Assessment, MSA multiple system atrophy, MSA-C multiple system atrophy-cerebellar type, MSA-P multiple system atrophy-parkinsonian type, NfL neurofilament light, NPI Neuropsychiatric Inventory, p-tau phosphorylated tau, RBDSQ Rapid eye movement sleep behavior disorder screening questionnaire, ROCF Rey-Osterreich Complex Figure, SARA Scale for the Assessment and Rating of Ataxia, SCWT Stroops Color Word Test, TMT Trails Making Test, UMSARS Unified Multiple System Atrophy Rating Scale, VFT Verbal Fluency Test, ZBI Zarit Caregiver Burden Interview.
