Table 1 Epigenetic Age Acceleration (EAA) measures in the study groups.

From: Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder

 

Parameter

CTR_pop (mean ± sd)

CTR_neg (mean ± sd)

iRBDs (mean ± sd)

iRBDs vs CTR_pop p-value

iRBDs vs CTR_neg p-value

Horvath calculator

Horvath-EAA

0 ± 4.87

0.42 ± 4.78

3.74 ± 5.57

0.189

0.063

intrinsic-EAA

0 ± 3.04

−0.90 ± 5.92

3.78 ± 6.77

0.285

0.055

extrinsic-EAA

0 ± 6.77

2.23 ± 5.62

3.78 ± 4.34

0.208

0.381

Hannum-EAA

0 ± 5.16

1.41 ± 4.34

2.56 ± 3.73

0.286

0.350

Skin&Blood-EAA

0 ± 3.96

1.07 ± 3.66

1.58 ± 3.44

0.205

0.452

PhenoAge-EAA

0 ± 6.83

1.92 ± 6.6

3.37 ± 4.62

0.132

0.451

GrimAge-EAA

0 ± 3.58

−0.63 ± 3.79

1.04 ± 4.41

0.850

0.222

Higgins-Chen calculator

PCHorvath-EAA

0 ± 4.97

1.71 ± 4.55

4.71 ± 4.48

0.028

0.031

PCHannum-EAA

0 ± 5.41

1.45 ± 4.40

3.25 ± 4.13

0.083

0.124

PCSkin&Blood-EAA

0 ± 5.54

2.09 ± 4.73

6.79 ± 6.06

0.016

0.006

PCPhenoAge-EAA

0 ± 6.28

2.20 ± 5.32

2.65 ± 4.43

0.133

0.421

PCGrimAge-EAA

0 ± 2.8

0.39 ± 3.01

2.07 ± 3.01

0.202

0.130

 

DunedinPACE

0.92 ± 0.11

0.96 ± 0.10

1.02 ± 0.11

0.131

0.125

  1. CTR_pop controls taken from the general population, CTR_neg controls negative for REM Sleep Behaviour Disorder (RBD) at videopolysomnography, iRBDs isolated RBD patients, sd standard deviation. Statistically significant results are in bold.
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