Fig. 1: Overview of local and global genetic correlations between neurodegenerative diseases and neuropsychiatric disorders.
From: Local genetic correlations exist among neurodegenerative and neuropsychiatric diseases
a Chord diagram showing the number of significant bivariate local \(r_g\) s (p < 0.05/1603) between each of the disease traits across all LD blocks. Positive and negative correlations are coloured red and blue, respectively. b Comparison between the global \(r_g\) s estimated by LDSC (bottom) and the mean local \(r_g\) from LAVA (top) across all tested LD blocks. Significant global \(r_g\) s (p < 0.05/15) are indicated with *. The number of significant local \(r_g\) s is indicated by a number in each tile. c Bar plot showing the number of significant local \(r_g\) s between disease trait pairs. The fill of the bars indicates the number of significant LD blocks for which the upper limit of the \(r^2\) 95% confidence interval (CI) included 1.
