Table 1 Overview of traits included in this study.

From: Local genetic correlations exist among neurodegenerative and neuropsychiatric diseases

Trait type

Trait

Abbreviation

N

N cases

N controls

Chr

Global h2 (SE)

h2 Z-score

Original study

Disease

Alzheimer’s disease

Clinically diagnosed + UK Biobank proxy cases and controls

AD

455,258

71,880

(46,613 proxy)

383,378

(318,246 UK biobank)

1-22

1.5% (0.2)

7.14

Jansen et al.26

Disease

Alzheimer’s disease

Clinically diagnosed

AD (no proxy)

63,926

21,982

41,944

1-22

7.1% (1.1)

6.25

Kunkle et al.27

Disease

Bipolar disorder

Clinically diagnosed + UK Biobank self-report during interview with nursea

BIP

413,466

41,917

(1116 self-report)

371,549

(58,113 UK biobank)

1-22

7.1% (0.3)

26.2

Mullins et al.28

Disease

Lewy body dementia

Autopsy-confirmed + clinically diagnosed

LBD

6618

2591

(1789 autopsy-confirmed)

4,027

1-22

17.1% (7.6)

2.27

Chia et al.5

Disease

Major depressive disorder excluding 23andMe

Clinically diagnosed (33 PGC cohorts) + UK Biobank broad depression phenotypeb

MDD

500,199

170,756

(127,552 UK Biobank broad depression)

329,443

(233,763 UK Biobank)

1-22

6% (0.2)

26

Howard et al.29

Disease

Parkinson’s disease excluding 23andMe

Clinically diagnosed + UK Biobank proxy cases and controls

PD

482,730

33,674

(18,618 proxy)

449,056

(436,419 UK biobank)

1-22

1.9% (0.2)

10.9

Nalls et al.3

Disease

Parkinson’s disease excluding 23andMe

Clinically diagnosed

PD (no proxy)

27,693

15,056

12,637

1-22

30.6% (2.8)

11.1

Nalls et al.3

Disease

Schizophrenia

Clinically diagnosed

SCZ

105,318

40,675

64,643

1-22, X

41% (1.4)

29.7

Pardiñas et al.30

Gene expression

eQTLGen

Blood-derived eQTLs

eQTLGEN

31,684

–

–

1-22

–

 

Vosã et al.42

Gene expression

PsychENCODE

Brain-derived eQTLs

PSYCHENCODE

1387

–

–

1-22

–

 

Wang et al.43

  1. Global observed-scale SNP heritability (h2) for each trait computed using LDSC66 assuming a continuous liability (which may differ from liability scale h2 estimates). The h2 Z-score was calculated by dividing the global h2 estimate by its standard error (SE).
  2. Chr chromosome.
  3. aUK Biobank participants were classified as having bipolar disorder if they had a reported clinical diagnosis of bipolar disorder (N = 777) or if they self-reported bipolar disorder during an interview with a nurse at baseline recruitment (N = 1116; union N = 1454).
  4. bUK Biobank broad depression determined by the participants’ response at recruitment to the question: “Have you ever seen a GP/psychiatrist for nerves, anxiety, tension or depression?”.
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