Fig. 4: Hemiparkinsonian rats have reduced activity in the Raphé magnus.
From: Periaqueductal grey and spinal cord pathology contribute to pain in Parkinson’s disease
a Number of c-FOS+ detections in sham- (n = 12) and 6-OHDA (n = 11) lesioned rats in the dorsal horn of the spinal cord after being administered intra-plantar capsaicin. Representative images of the sham and 6-OHDA lesioned rat dorsal horns are displayed above magnified images of the dotted box area of ipsi- and contralateral dorsal horns for visual comparison. b Number of c-FOS+ cell detections (i) and TPH+/c-FOS+ cell detections (ii) in the RMg with representative figures of sham and 6-OHDA lesioned rats, along with higher magnification images of the dotted box area. All data are represented as mean ± SEM. For histological analyses, Kruskal–Wallis with Dunn’s multiple comparisons tests were performed for spinal cord analysis, and RMg analyses were performed with unpaired t tests. * indicates that P < 0.05. All images were counterstained using haematoxylin. All scale bars = 50 µm.
