Table 1 Demographic data and main SAA results.

From: Combining skin and olfactory α-synuclein seed amplification assays (SAA)—towards biomarker-driven phenotyping in synucleinopathies

 

PD (N = 27)

RBD (N = 18)

Atypical parkinsonism (N = 6)

Control (N = 30)

P-value

Sex: female

7 (25.9%)

3 (16.7%)

4 (66.7%)

13 (43.3%)

0.063

Male

20 (74.1%)

15 (83.3%)

2 (33.3%)

17 (56.7%)

Age, mean (SD)

64.0 (8.78)

65.9 (6.99)

69.4 (4.74)

60.7 (11.1)

0.098

H&Y stage: mean (SD)

2.56 (0.70)

3.00 (0.89)

0.189

Duration, years: mean (SD)

12.4 (5.62)

8.21 (7.07)

3.33 (2.42)

0.003

Positive nasal brushing SAA, N (% of sampled)

13 (48.1%)

12 (67%): 8 right-sided (44.4%), 11 (61.1%) left-sided

1/3 MSA, 0/3 PSP

3 (10.0%)

<0.001

Positive skin biopsy SAA, N/total: (% of sampled)

15/19 (78.9%)

15/15 (100%)

3/3 MSA, 0/3 PSP

NA

0.113 for PD vs. iRBD

Thigh

12 (70.6%)

14 (93.3%)

3 (60.0%)

NA

0.095 for PD vs. iRBD

Neck (C7)

9 (47.4%)

13 (86.7%)

3 (60.0%)

NA

0.043 for PD vs. iRBD