Fig. 10: IHC analysis of the animals involved in the in vivo study. | npj Parkinson's Disease

Fig. 10: IHC analysis of the animals involved in the in vivo study.

From: AAV-mediated expression of a new conformational anti-aggregated α-synuclein antibody prolongs survival in a genetic model of α-synucleinopathies

Fig. 10

Formalin-fixed brain tissue from all animals included in the study were tested via pSer129-α-synuclein immunohistochemistry for strong pathology, corresponding to the symptom of loss of righting reflex at time of euthanasia. Examples of the obtained staining’s for representative animals from each cohort are shown (a–e). See Supplementary Table 1 for details on the individual animals. High magnifications of the indicated areas are shown above and below the full brain images. CC cerebral cortex, Hi hippocampus, Mb midbrain, Th thalamus, Ce cerebellum, Me medulla. Scale bar full brain image: 1 mm, higher magnifications: 50 μm.

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