Fig. 3: MRgFUS successfully alleviated tremor in the target hand.

CRST tremor scores are shown for all 13 patients (TDPD and ET; top), for the target hand (left) and non-target hand (right), at each time point. There was a significant decrease in average target hand CRST tremor scores following the intervention (F(4,48) = 40.07, p < 0.001; top left). Scores decreased from baseline at all time points (all p’s < 0.001, Sidak correction; see Table 2). There was also a decrease in UPDRS-III target hand tremor scores after the procedure (F(4,36) = 26.70, p < 0.001; bottom left), which was significant at all time points (all p’s < 0.01, Sidak correction; see Table 2). Meanwhile, as expected, depending on the scale used, tremor in the non-target hand either increased following the intervention (CRST: F(4,48) = 3.01, p = 0.027, although post-hoc tests showed no significant different from baseline at any time point; top right) or did not change (UPDRS-III: F(4,36) = 1.35, p > 0.05; bottom right). Error bars represent standard errors of the mean. Each line connects datapoints from a given participant.