Fig. 2: Schematic of the LRRK2 domain structure.

Above the schematic, key amino acid substitutions are indicated that alter risk for PD, including mutations that increase risk for PD such as pathogenic mutations (red) and risk factor mutations (blue) as well as mutations that confer reduced risk for PD (green). Phosphorylated residues are given below the schematic, with heterologous phosphosites give in blue and autophosphorylation sites in red. Figure adapted from ref. ²².