Table 1 Mendelian randomization (MR) results of LRRK2-associated proteins for being causal for PD.

SDCBP2

X19261.12

1

7.3 × 10^{−21 B}

0.562

NA

NA

NA

NA

NA

NA

GPNMB

X8606.39

1

9.03 × 10^{−20 B}

0.201

1

9.03 × 10^{−20 B}

0.201

1

9.03 × 10^{−20 B}

0.201

CD68

X18922.27

4

7.58 × 10^{−11 A}

0.219

3

0.011^A

0.193

1

4.01 × 10^{−5 B}

0.270

CD68

X20528.23

4

0.001^A

0.210

3

0.220^A

0.183

NA

NA

NA

LCT

X9017.58

3

0.005^A

0.050

3

0.005^A

0.050

1

0.006^B

0.050

ENTPD1

X3182.38

2

0.011^A

0.293

1

0.793^B

0.022

NA

NA

NA

ITGB2

X12750.9

3

0.022^A

0.294

2

0.061^A

0.134

NA

NA

NA

GPNMB

X8240.207

3

0.031^A

0.189

2

7.99 × 10^{−7 A}

0.147

1

9.03 × 10^{−20 B}

0.153

C1QTNF1

X6304.8

2

0.041^A

0.293

1

0.903^B

−0.010

NA

NA

NA

GPNMB

X5080.131

3

0.049^A

0.166

2

7.25 × 10^{−12 A}

0.132

1

9.03 × 10^{−20 B}

0.135

HLA-DQA2

X7757.5

2

0.967^A

−0.013

1

8.27 × 10^{−13 B}

−0.195

1

8.27 × 10^{−13 B}

−0.195

GRN

X4992.49

2

0.552^A

0.197

1

4.78 × 10^{−5 B}

−0.262

1

4.78 × 10^{−5 B}

−0.262

GAA

X9385.4

1

0.141^B

−0.112

1

0.141^B

−0.112

1

0.141^B

−0.112

LGALS9

X9197.4

2

0.200^A

−0.049

2

0.200^A

−0.049

NA

NA

NA

TLR3

X16918.198

2

0.746^A

0.055

1

0.382^B

−0.018

1

0.382^B

−0.018

AGFG2

X23597.11

2

0.420^A

0.034

2

0.420^A

0.034

1

0.881^B

0.007

TMEM106A

X10499.1

2

0.073^A

0.314

1

0.436^B

0.053

NA

NA

NA

CHIT1

X3600.2

4

0.730^A

−0.006

4

0.730^A

−0.006

1

0.803^B

0.004

OLR1

X3636.37

2

0.992^A

−4.63 × 10⁻⁴

1

0.793^B

0.021

NA

NA

NA

OLR1

X7893.19

2

0.993^A

−4.53 × 10⁻⁴

1

0.793^B

0.021

NA

NA

NA

GREM2

X5598.3

2

0.115^A

1.808

1

0.828^B

−0.058

NA

NA

NA