Table 2 Crude and adjusted hazard ratios of Parkinson’s disease for various cancers.

From: Longitudinal study of the inverse relationship between Parkinson’s disease and cancer in Korea

 

Incident rate per 1000 person-year

Incident rate difference per 1000 person-years (95% CI)

Hazard ratio for cancer (95% CI)

PD

Control

Crudeb

P-value

Model 1b,c

P-value

Model 2b,c,d

P-value

Overall cancer (n = 3165)

11.52

14.09

−2.57 (−3.82 to −1.32)

0.82 (0.74–0.91)

<0.001a

0.62 (0.56–0.68)

<0.001a

0.63 (0.57–0.69)

<0.001a

Gastric cancer (n = 689)

2.70

2.95

−0.25 (−0.82 to 0.32)

0.91 (0.75–1.12)

0.387

0.68 (0.56–0.84)

<0.001a

0.69 (0.56–0.85)

<0.001a

Thyroid cancer (n = 160)

0.57

0.69

−0.11 (−0.39 to 0.16)

0.76 (0.49–1.17)

0.216

0.58 (0.38–0.90)

0.015a

0.60 (0.39–0.93)

0.022a

Colorectal cancer (n = 637)

1.98

2.81

−0.83 (−1.37 to −0.28)

0.71 (0.56–0.89)

0.004a

0.55 (0.44–0.70)

<0.001a

0.56 (0.44–0.70)

<0.001a

Lung cancer (n = 756)

2.71

3.24

−0.53 (−1.12 to 0.06)

0.86 (0.71–1.06)

0.153

0.69 (0.57–0.85)

<0.001a

0.71 (0.58–0.87)

0.001a

Hepatic cancer (n = 364)

1.26

1.57

−0.31 (−0.72 to 0.10)

0.83 (0.62–1.11)

0.197

0.64 (0.47–0.86)

0.003a

0.64 (0.48–0.86)

0.003a

Bladder cancer (n = 194)

0.69

0.83

−0.14 (−0.44 to 0.16)

0.86 (0.58–1.28)

0.462

0.71 (0.48–1.06)

0.091

0.71 (0.48–1.06)

0.091

Pancreatic cancer (n = 201)

0.45

0.91

−0.46 (−0.77 to −0.16)

0.50 (0.31–0.80)

0.004a

0.36 (0.22–0.58)

0.001a

0.37 (0.23–0.60)

0.001a

Gallbladder and biliary duct cancer (n = 201)

0.88

0.82

0.05 (−0.25 to 0.36)

1.07 (0.75–1.52)

0.730

0.85 (0.59–1.23)

0.389

0.87 (0.61–1.26)

0.461

Kidney cancer (n = 92)

0.52

0.35

0.17 (−0.03 to 0.38)

1.41 (0.87–2.28)

0.161

1.14 (0.70–1.85)

0.606

1.14 (0.70–1.86)

0.597

Hematological malignancy (n = 175)

0.55

0.76

−0.22 (−0.50 to 0.06)

0.70 (0.45–1.08)

0.109

0.56 (0.36–0.88)

0.011a

0.56 (0.36–0.87)

0.010a

  1. CI confidence interval, PD Parkinson’s disease.
  2. aStratified Cox proportional hazard regression model, Significance at P < 0.05.
  3. bStratified by age, sex, income, and region of residence.
  4. cAdjusted for obesity, smoking, alcohol consumption, and Charlson Comorbidity Index scores.
  5. dAdjusted for systolic blood pressure, diastolic blood pressure, fasting blood glucose, and total cholesterol.