Table 1 Group demographics of cases used in this study based on clinicopathological diagnosis.
From: α-Synuclein pathology in post-mortem retina and optic nerve is specific for α-synucleinopathies
Controls | Parkinson’s disease (dementia) | Dementia with Lewy bodies | Multiple system atrophy | Alzheimer’s disease | Other neurodegenerative diseases | |
|---|---|---|---|---|---|---|
MSA-p, MSA-c/p | Primary tauopathies, FTLD, ALS, MS, Fragile X syndrome, vascular dementia, hydrocephalus | |||||
n = 25 | n = 21 | n = 5 | n = 7 | n = 19 | n = 22 | |
Female, n | 18 | 7 | 3 | 5 | 12 | 9 |
Age at death mean ± SD | 72 ± 16 | 77 ± 9 | 81 ± 8 | 70 ± 9 | 77 ± 9 | 70 ± 14 |
Disease duration median; min–max | n/a | 192 (37–324) | 72 (48–84) | 60 (24–120) | 108 (12–312) | 84 (24–180) |
Presence of visual hallucinations, n | 0 | 13 | 5 | 0 | 1 | 2 |
Presence of dementia, n | 0 | 9 | 3 | 1 | 16 | 9 |
Braak stage for LB median; min–max | 0 (0–4) | 6 (3–6) | 6 (4–6) | 4 (3–5) | 0 (0–4) | 0 (0–3) |
LPC stage | 0 (0–4) | 5 (3–5) | 5 (5) | 5 (3–5) | 0 (0–4) | 0 (0–3) |
Post-mortem interval eyes median; min–max | 8 (3–30) | 6 (4–10) | 7 (5–10) | 6 (5–9) | 7 (5–16) | 6 (4–18) |
