Fig. 1: Distribution of GBA1 variants in patients with PD and control.

Schematic drawing of the gene and the protein domains, and diagram of reported and newly discovered GBA1 variants. Note: Different colors indicate different types of GBA1 variants. Red indicates reported severe variants, Pink indicates novel severe variants, which means variants are loss of function variants or variants were reported in Gaucher’s patients and were defined severe but were unreported in PD, Yellow indicates mild variants, Blue indicates risk variants, Black indicates reported variants of unknown significance, and green indicates novel missense variants. PD Parkinson’s Disease.