Fig. 5: Neuronal loss is observed in the CA2/3 hippocampal subfield. | npj Parkinson's Disease

Fig. 5: Neuronal loss is observed in the CA2/3 hippocampal subfield.

From: Hippocampal subfield vulnerability to α-synuclein pathology precedes neurodegeneration and cognitive dysfunction

Fig. 5

Quantification of NeuN-positive immunostaining in the (A) dentate gyrus, (B) CA1 subfield, and (C) CA2/3 subfield. Data are expressed as boxplots depicting the median, interquartile range, and individual data points for NeuN-positive area normalized to control at 1, 3, and 6 MPI in the (A) dentate gyrus, (B) CA1 subfield, and (C) CA2/3 subfield (n = 6–12 animals/group/time point). ****p < 0.0001 by two-way ANOVA with Bonferroni’s multiple comparisons test, as indicated. D Representative images of NeuN immunostaining in the hippocampus and CA2/3 subfield in control (left columns) and fibril-injected mice (right columns) at 1, 3, and 6 MPI. Scale bar: 500 μm (hippocampus) or 100 μm (CA2/3 subfield).

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