Fig. 7: Cognitive performance is associated with neuronal loss in the CA2/3 subfield but not residual α-synuclein burden. | npj Parkinson's Disease

Fig. 7: Cognitive performance is associated with neuronal loss in the CA2/3 subfield but not residual α-synuclein burden.

From: Hippocampal subfield vulnerability to α-synuclein pathology precedes neurodegeneration and cognitive dysfunction

Fig. 7

A, C, E Association between average latency in the Barnes maze at 6 MPI and (A, C, E) NeuN levels in the (A) dentate gyrus, (C) CA1 subfield, and (E) CA2/3 subfield in the 6 MPI cohort. **p < 0.01 by Spearman correlation, r values listed by region, as indicated. B, D, F Association between average latency at 6 MPI and (B, D, F) pS129-α-synuclein immunostaining in the (B) dentate gyrus, (D) CA1 subfield, and (F) CA2/3 subfield at 6 MPI. Not significant by Spearman correlation, r values listed by region, as indicated.

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