Table 3 Mediation analysis for the mechanism of PD-related underweight mediated by intestinal microbial alteration with different measures as mediators: (A) genus level; and (B) species level.
(A) | |||||
|---|---|---|---|---|---|
Effect of PD on underweight (95% CI) | Effect of PD on microbiota (95% CI) | Effect of microbiota on underweight (95% CI) | PM (%) | P-value | |
Unadjusted | 1.8079 (0.3013, 3.3145) | ||||
Adjusted for | |||||
All genera | 1.0433 | 42.29 % | |||
Agathobacter | 1.4788 (0.1098, 2.8478) | −2.1187 (−3.0017, −1.2357) | −0.2151 (−0.3478, −0.0824) | 18.20 % | 0.0016 |
Eisenbergiella | 1.6143 (0.3160, 2.9126) | 1.0614 (0.2804, 1.8424) | 0.1966 (0.0370, 0.3561) | 10.71 % | 0.0162 |
Fusicatenibacter | 1.4626 (0.0136, 2.9116) | −1.6858 (−2.4641, −0.9075) | −0.1959 (−0.3688, −0.0230) | 19.10 % | 0.0269 |
Roseburia | 1.6373 (0.2010, 3.0736) | −1.5329 (−2.4245, −0.6413) | −0.152 (−0.2947, −0.0093) | 9.44 % | 0.0377 |
Ruminococcaceae_UCG_013 | 1.7027 (0.3834, 3.0220) | −0.9022 (−1.6531, −0.1513) | −0.1739 (−0.3434, −0.0044) | 5.82 % | 0.0451 |
(B) | |||||
|---|---|---|---|---|---|
Effect of PD on underweight (95% CI) | Effect of PD on microbiota (95% CI) | Effect of microbiota on underweight (95% CI) | PM (%) | P-value | |
Unadjusted | 1.8079 (0.3013, 3.3145) | ||||
Adjusted for | |||||
All species | 1.1224 | 37.91 % | |||
Fusicatenibacter_saccharivorans | 1.4446 (0.0487, 2.8405) | −1.6595 (−2.4485, −0.8704) | −0.2490 (−0.4304, −0.0675) | 20.10 % | 0.0076 |
Roseburia_inulinivorans | 1.5698 (0.2537, 2.8859) | −1.7441 (−2.6531, −0.8351) | −0.2935 (−0.5465, −0.0405) | 13.17 % | 0.0237 |
