Table 3 An overview of the literature about WM changes in PD using DTI.
Study | Objective studied | FA reductions | MD (AD and RD) increases |
|---|---|---|---|
Motor correlates | |||
Nazmuddin et al.64 | PIGD | PIGD < TD: bilaterally at the proximal portion of the medial NBM tract and the frontotemporal portal of the lateral NBM-WM tract; PD, PIGD < controls: fronto-lateral NBM-WM tract of the left hemisphere | |
Tan et al.65 | PIGD | PD, PIGD < controls: inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, anterior thalamic radiation | PD, PIGD > controls: superior longitudinal fasciculus, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, anterior thalamic radiation, and body of the corpus callosum; PIGD > PD: superior longitudinal fasciculus, genu of the corpus callosum, and body of the corpus callosum |
Wen et al.66 | PIGD | PIGD < TD: bilateral inferior longitudinal fasciculi, right posterior thalamic radiation, right superior and posterior corona radiata | PIGD > TD: bilateral inferior longitudinal fasciculi, bilateral posterior thalamic radiation, bilateral anterior and posterior corona radiata, left uncinate fasciculus |
Canu et al.67 | FOG | The primary motor, premotor, prefrontal, orbitofrontal, and inferior parietal cortices, cingulum, and superior longitudinal fasciculus bilaterally, and of the cerebral peduncles, corpus callosum (genu, anterior body, and splenium) and temporo-occipital WM tracts | The primary motor, premotor, prefrontal, orbitofrontal, and inferior parietal cortices, cingulum, and superior longitudinal fasciculus bilaterally, and of the cerebral peduncles, left corticospinal tract and thalamic radiations, external capsule, bilaterally, and cerebellum (right lobule VIII, and lobule IX, bilaterally) |
Fling et al.68 | FOG | PD-FOG vs. PD and Controls: PUT, internal GPi, cingulate, Thal, precentral and postcentral gyrus, superior and middle frontal gyrus, SMA, pre-SMA and bilateral cerebellar locomotor regions PPN fiber tract in the right hemisphere | |
Peterson et al.69 | FOG | Greater quantity in PPN tract in the right hemisphere; Correlation in FOG: lateralized PPN connectivity and larger dual task interference, stride length during normal and dual task walking | |
Vercruysse et al.71 | FOG | Left (lobule VI) and right (Crus I, lobule VIIIb) hemisphere of the cerebellum, left temporal part of the SLF; connections between the left caudate nucleus and ACC and orbitofrontal cortex, between the left middle CP and PPN | Right anterior part of the capsula interna and corona radiata, the superior frontal cortex, and a left-hemispheric cluster in cerebellum Crus II; connecting the caudate, PUT, GP, and STN to frontal (ACC, superior and orbitofrontal cortex), motor (pre-SMA, SMA) and sensory (S1 and S2) cortical regions predominantly in the left hemisphere |
Youn et al.72 | FOG | Bilateral PPN | Basal ganglia, Thal and cerebellum (in PPN tract); bilateral PPN |
Cognitive correlates | |||
Agosta et al.73 | MCI | PD-MCI vs. PD: bilateral anterior and superior corona radiata, CC genu and body anterior inferior IFOF/uncinate, anterior SLF; PD-MCI vs. Controls: bilateral anterior and superior corona radiata, CC body, anterior SLF | |
Kamagata et al.74 | PDD | PD < Controls: anterior cingulate bundle; PDD < Controls: anterior and posterior cingulate bundle | PD > Controls: anterior cingulate bundle |
Kamagata et al.75 | PDD | PDD < PD: anterior part of the IF-OF and in part of the genu of CC; PDD < Controls: SLF, ILF, IFOF, UF, cingulum, anterior limb of internal capsule, SN (all bilateral) | PDD > PD: anterior part of the IF-OF and in part of the genu of CC; PDD > Controls: SLF, ILF, IF-OF, UF, cingulum, anterior and posterior limb of internal capsule, SN (all bilateral) |
Bledsoe et al.76 | PDD | PD > Controls: callosal segment 1,2 and 3; PDD > PD-NC: callosal segment 1 and 2; PDD > PD-MCI: callosal segment 1 | |
Chondrogiorgi et al.77 | PDD | PDD < PD: the body of corpus callosum, bilaterally in superior corona radiata and cingulum (cingulate gyrus) and on the left side in anterior corona radiata, inferior fronto-occipital fasciculus (IFF), uncinate fasciculus, anterior thalamic radiation (ATR) and forceps minor | |
Mood correlates | |||
Surdhar et al.83 | Depression | ||
Prange et al.80 | Depression | PDD < Controls: anterior interhemispheric connections and limbic association tracts | |
Lacey et al.82 | Depression | ||
Surdhar et al.83 | Depression | ||
