Fig. 5: CD163KO females display dysfunctional astrocytic responses to α-syn PFF injection.
From: Sex-dimorphic neuroprotective effect of CD163 in an α-synuclein mouse model of Parkinson’s disease
a Representative images of GFAP immunostaining in α-syn PFF animals in the striatum, b piriform cortex and c amygdala at 1 month p.i. Scale: 50 μm applies to all. Bar graphs with individual points illustrate the percentage of area covered by GFAP+ staining after PBS, α-syn MONO and PFF injection in the d–h striatum, i–m piriform cortex and n–r amygdala at 1 month p.i. Values are mean ± SEM (n = 5–10). Statistics: two-way ANOVA followed by Sidak’s multiple comparison test. P values are given according to the number of symbols, e.g., *p < 0.05, **<0.01, ***<0.001, ****<0.0001. # different to the corresponding WT group.
