Fig. 3: Schematic illustration of the neuroanatomical structures investigated in this study for acetylated α-Tubulin distribution. | npj Parkinson's Disease

Fig. 3: Schematic illustration of the neuroanatomical structures investigated in this study for acetylated α-Tubulin distribution.

From: Linking acetylated α-Tubulin redistribution to α-Synuclein pathology in brain of Parkinson’s disease patients

Fig. 3

Both the central (CNS) and the peripheral nervous system (PNS) of PD patients were immunostained, analyzed, and the changes observed in the neuronal cell body and in the axonal compartment are indicated in green and red, respectively. Acetylated α-Tubulin is increased in the neuronal cell bodies in DMV, LC, SN and Putamen, whereas it remained unchanged in the cerebral cortex (PFC, Cing, and EC). Acetylated α-Tubulin is decreased in the axons of putamen and in the PNS namely in the axon innervating sweat gland. Cing cingulum; DMV dorsal motor nucleus of vagus; EC entorhinal cortex; LC locus coeruleus; SN substantia nigra; PFC prefrontal cortex; Pu putamen.

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