Fig. 2: Variants passing Bonferroni correction and 80% power.
From: Analysis of rare Parkinson’s disease variants in millions of people
Results 1: Forest plot showing five variants passing Bonferroni correction at p < 7.4E-05 in the meta-analysis and reaching 80% statistical power at OR = 2 and alpha = 0.05. Results 2: Forest plot showing five strong candidate variants passing Bonferroni correction at p < 7.4E-05 but did not reach 80% power at OR = 2 (right). Three variants passed p < 0.05, have previously been linked to PD, and are located in dominantly inherited genes. All variants had calculated ORs greater than 2 in the meta-analysis, suggesting that they are good candidates to reach 80% power at higher OR calculations. Data is based on OR (dot) and 95% CI (error bar) and for visualization purposes the x-axis is on a log scale. Colors indicate clinical significance of the variant: Conflicting/uncertain/unknown (red), pathogenic (green), and pathogenic/risk factor (blue) based on ClinVar annotations.
